Transmission Disequilibrium Test (TDT) when Only One Parent Is Available The 1-TDT
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چکیده
منابع مشابه
Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT.
The transmission disequilibrium test (TDT) is a useful method to locate mutations linked to disease genes associated with complex diseases. TDT requires genotypes of affected individuals and their parents. Recently, Ewens and Spielman (Am J Hum Genet 1998;62:450-8) extended the TDT for use in sibships with at least one affected and one unaffected individual and devised a new test called the sib...
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The transmission disequilibrium test (TDT) customarily uses affected children and their parents (often case-parent trios, TDTD). Control-parent trios are necessary to guard against spurious significant results due to segregation distortion but are not generally utilized in the identification of disease susceptibility loci (DSL). Controls are often easy to recruit and the TDT can easily be exten...
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The transmission/disequilibrium test (TDT) is widely used to detect the linkage disequilibrium between a candidate locus (a marker) and a disease locus. The TDT is a family-based design and has the advantage that it is a valid test when population stratification exists. The TDT requires the marker genotypes of affected individuals and their parents. For diseases with late age of onset, it is di...
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The transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete triads. Some strategies assumed that parental genotypes were missing completely at random and some methods allowed informative missingness for parental genotypes. However, t...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 1999
ISSN: 0002-9262,1476-6256
DOI: 10.1093/oxfordjournals.aje.a009923